Increased erbB3 promotes erbB2/neu-driven mammary tumor proliferation and co-targeting of erbB2/erbB3 receptors exhibits potent inhibitory effects on breast cancer cells

The kinase deficient erbB3 receptor frequently co-expresses and interacts with erbB2 in human breast cancer to activate the oncogenic signaling pathways, and thus promote breast cancer cell survival/proliferation. In the current study, we discovered that the expression of endogenous mouse erbB3 was...

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Publicado en:Int J Clin Exp Pathol
Autores principales: Lyu, Hui, Huang, Jingcao, Edgerton, Susan M, Thor, Ann D, He, Zhimin, Liu, Bolin
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525826/
https://ncbi.nlm.nih.gov/pubmed/26261492
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