STAT3 regulated ARF expression suppresses prostate cancer metastasis

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient...

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Publicado en:Nat Commun
Autores principales: Pencik, Jan, Schlederer, Michaela, Gruber, Wolfgang, Unger, Christine, Walker, Steven M., Chalaris, Athena, Marié, Isabelle J., Hassler, Melanie R., Javaheri, Tahereh, Aksoy, Osman, Blayney, Jaine K., Prutsch, Nicole, Skucha, Anna, Herac, Merima, Krämer, Oliver H., Mazal, Peter, Grebien, Florian, Egger, Gerda, Poli, Valeria, Mikulits, Wolfgang, Eferl, Robert, Esterbauer, Harald, Kennedy, Richard, Fend, Falko, Scharpf, Marcus, Braun, Martin, Perner, Sven, Levy, David E., Malcolm, Tim, Turner, Suzanne D., Haitel, Andrea, Susani, Martin, Moazzami, Ali, Rose-John, Stefan, Aberger, Fritz, Merkel, Olaf, Moriggl, Richard, Culig, Zoran, Dolznig, Helmut, Kenner, Lukas
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525303/
https://ncbi.nlm.nih.gov/pubmed/26198641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8736
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