STAT3 regulated ARF expression suppresses prostate cancer metastasis

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Pencik, Jan, Schlederer, Michaela, Gruber, Wolfgang, Unger, Christine, Walker, Steven M., Chalaris, Athena, Marié, Isabelle J., Hassler, Melanie R., Javaheri, Tahereh, Aksoy, Osman, Blayney, Jaine K., Prutsch, Nicole, Skucha, Anna, Herac, Merima, Krämer, Oliver H., Mazal, Peter, Grebien, Florian, Egger, Gerda, Poli, Valeria, Mikulits, Wolfgang, Eferl, Robert, Esterbauer, Harald, Kennedy, Richard, Fend, Falko, Scharpf, Marcus, Braun, Martin, Perner, Sven, Levy, David E., Malcolm, Tim, Turner, Suzanne D., Haitel, Andrea, Susani, Martin, Moazzami, Ali, Rose-John, Stefan, Aberger, Fritz, Merkel, Olaf, Moriggl, Richard, Culig, Zoran, Dolznig, Helmut, Kenner, Lukas
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525303/
https://ncbi.nlm.nih.gov/pubmed/26198641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8736
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items