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Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice

Pulmonary exposure to cadmium, a major component of cigarette smoke, has a dramatic impact on lung function and the development of emphysema. Cigarette smoke exposure induces heme oxygenase-1 (HO-1), a cytoprotective enzyme. In this study, we employed a truncated mouse model of emphysema by intratra...

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Publicado en:Am J Physiol Lung Cell Mol Physiol
Main Authors: Surolia, Ranu, Karki, Suman, Kim, Hyunki, Yu, Zhihong, Kulkarni, Tejaswini, Mirov, Sergey B., Carter, A. Brent, Rowe, Steven M., Matalon, Sadis, Thannickal, Victor J., Agarwal, Anupam, Antony, Veena B.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525122/
https://ncbi.nlm.nih.gov/pubmed/26071551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00097.2015
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