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Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells
Glycosphingolipids (GSLs) play a role in insulin resistance and diabetes, but their role in diabetic nephropathy (DN) has received limited attention. We used 9- and 17-wk-old nondiabetic db/m and diabetic db/db mice to examine the role of GSLs in DN. Cerebrosides or monoglycosylated GSLs [hexosylcer...
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| Publicado no: | Am J Physiol Renal Physiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4525094/ https://ncbi.nlm.nih.gov/pubmed/26041445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00150.2015 |
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