Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy

Abnormal intracellular calcium (Ca(2+)) handling can trigger endoplasmic reticulum (ER) stress, leading to activation of the unfolded protein response (UPR) in an attempt to prevent cell death. Mechanical unloading with a left ventricular assist device (LVAD) relieves pressure-volume overload and pr...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Castillero, Estibaliz, Akashi, Hirokazu, Pendrak, Klara, Yerebakan, Halit, Najjar, Marc, Wang, Catherine, Naka, Yoshifumi, Mancini, Donna, Sweeney, H. Lee, D′Armiento, Jeanine, Ali, Ziad A., Schulze, P. Christian, George, Isaac
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
Témata:
Muscle Mechanics and Ventricular Function
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525088/
https://ncbi.nlm.nih.gov/pubmed/26055788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00056.2015
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