Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: outcomes for genetic screening techniques

A combined approach, comprising PCR screening and genome mining, was used to unravel the diversity and phylogeny of genes encoding 5-aminolevulinic acid synthases (ALASs, hemA gene products) in streptomycetes-related strains. In actinomycetes, these genes were believed to be directly connected with...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Petříčková, Kateřina, Chroňáková, Alica, Zelenka, Tomáš, Chrudimský, Tomáš, Pospíšil, Stanislav, Petříček, Miroslav, Krištůfek, Václav
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525017/
https://ncbi.nlm.nih.gov/pubmed/26300877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00814
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