Stress impairs prefrontal cortical function via D1 dopamine receptor interactions with HCN channels

BACKGROUND: Psychiatric disorders such as schizophrenia are worsened by stress, and working memory deficits are often a central feature of illness. Working memory is mediated by the persistent firing of prefrontal cortical (PFC) pyramidal neurons. Stress impairs working memory via high levels of dop...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: Gamo, Nao J., Lur, Gyorgy, Higley, Michael J., Wang, Min, Paspalas, Constantinos D., Vijayraghavan, Susheel, Yang, Yang, Ramos, Brian P., Peng, Kathy, Kata, Anna, Boven, Lindsay, Lin, Faith, Roman, Lisette, Lee, Daeyeol, Arnsten, Amy F.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524795/
https://ncbi.nlm.nih.gov/pubmed/25731884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.01.009
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