Hyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease

Differential modulation of NF-κB during meningococcal infection is critical in innate immune response to meningococcal disease. Non-invasive isolates of Neisseria meningitidis provoke a sustained NF-κB activation in epithelial cells. However, the hyperinvasive isolates of the ST-11 clonal complex (S...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Besbes, Anissa, Le Goff, Salomé, Antunes, Ana, Terrade, Aude, Hong, Eva, Giorgini, Dario, Taha, Muhamed-Kheir, Deghmane, Ala-Eddine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524725/
https://ncbi.nlm.nih.gov/pubmed/26241037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005078
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