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Heterocycle-to-Heterocycle Route to Quinoline-4-amines: Reductive Heterocyclization of 3-(2-Nitrophenyl)isoxazoles

A variety of quinoline-4-amines were synthesized from substituted 3-(2-nitrophenyl)isoxazoles utilizing Zn(0) or Fe(0) dust and HOAc via a reductive heterocyclization process. The starting isoxazoles were synthesized from readily available starting materials. A brief survey of functional groups tole...

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Bibliografske podrobnosti
izdano v:European J Org Chem
Main Authors: Coffman, Keith C., Duong, Vy, Bagdasarian, Alex L., Fettinger, James C., Haddadin, Makhlouf J., Kurth, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524663/
https://ncbi.nlm.nih.gov/pubmed/26257574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201403065
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