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One-pot directed alkylation/deprotection strategy for the synthesis of substituted pyrrole[3,4-d]pyridazinones

In the course of an SAR study of pyrrole[3,4-d]pyridazinones we optimized conditions for a one pot directed lithiation / alkylation reaction that also promoted in situ cleavage of a Boc-protecting group on the pyrrole ring. The efficiency of the process allowed access to a number of substituted anal...

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Detalhes bibliográficos
Publicado no:European J Org Chem
Main Authors: Nair, Reji N., Bannister, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524656/
https://ncbi.nlm.nih.gov/pubmed/26257580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201403491
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