The semidominant Mi(b) mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerization.

The mouse microphthalmia (mi) locus encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor called MITF (microphthalmia transcription factor). Mutations at mi affect the development of several different cell types, including melanocytes, mast cells, osteoclasts and pigmented...

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Detalhes bibliográficos
Main Authors: Steingrímsson, E, Nii, A, Fisher, D E, Ferré-D'Amaré, A R, McCormick, R J, Russell, L B, Burley, S K, Ward, J M, Jenkins, N A, Copeland, N G
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452451/
https://ncbi.nlm.nih.gov/pubmed/8947051
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