The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.

Trivalent arsenic (As3+) is highly carcinogenic, but devoid of known mutagenic activity. Therefore, it is likely to act as a tumor promoter. To understand the molecular basis for the tumor-promoting activity of As3+, we examined its effect on transcription factor AP-1, whose activity is stimulated b...

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Udgivet i:EMBO J
Main Authors: Cavigelli, M, Li, W W, Lin, A, Su, B, Yoshioka, K, Karin, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452450/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8947050/
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