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Insertion of Proteolipid Protein into Oligodendrocyte Mitochondria Regulates Extracellular pH and ATP

Proteolipid protein (PLP) and DM20, the most abundant myelin proteins, are coded by the human PLP1 and non-human Plp1 proteolipid protein gene. Mutations in the PLP1 gene cause Pelizaeus-Merzbacher Disease (PMD) with duplications of the native PLP1 gene accounting for 70% of PLP1 mutations. Humans w...

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Detalles Bibliográficos
Publicado en:Glia
Main Authors: Appikatla, Sunita, Bessert, Denise, Lee, Icksoo, Hüttemann, Maik, Mullins, Chadwick, Somayajulu-Nitu, Mallika, Yao, Fayi, Skoff, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524290/
https://ncbi.nlm.nih.gov/pubmed/24382809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22591
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