A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens

We evaluated a genital herpes prophylactic vaccine containing herpes simplex virus 2 (HSV-2) glycoproteins C (gC2) and D (gD2) to stimulate humoral immunity and U(L)19 (capsid protein VP5) and U(L)47 (tegument protein VP13/14) as T cell immunogens. The HSV-2 gC2 and gD2 proteins were expressed in ba...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Awasthi, Sita, Mahairas, Gregory G., Shaw, Carolyn E., Huang, Meei-Li, Koelle, David M., Posavad, Christine, Corey, Lawrence, Friedman, Harvey M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524253/
https://ncbi.nlm.nih.gov/pubmed/26041292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01089-15
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