Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

Genetic predisposition to neoplasia often involves tumor suppressor genes. One such model of hereditary renal carcinoma was described in the rat by Eker. These tumors share morphologic similarities with human renal cancer. Linkage analysis localized the inherited mutation to rat chromosome band 10q1...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Yeung, R S, Xiao, G H, Jin, F, Lee, W C, Testa, J R, Knudson, A G
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11413
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