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Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.

Telomerase is a ribonucleoprotein that catalyzes telomere elongation through the addition of TTAGGG repeats in humans. Activation of telomerase is often associated with immortalization of human cells and cancer. To dissect the human telomerase enzyme mechanism, we developed a functional in vitro rec...

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Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Autexier, C, Pruzan, R, Funk, W D, Greider, C W
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1996
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452365/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8918470/
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