DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling

The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular dopamine in the nucleus accumbens (NAc) are traditionally thought to result from cocaine’s ability to block...

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Publicado en:Mol Psychiatry
Main Authors: Northcutt, A.L., Hutchinson, M.R., Wang, X., Baratta, M.V., Hiranita, T., Cochran, T.A., Pomrenze, M.B., Galer, E.L., Kopajtic, T.A., Li, C.M., Amat, J., Larson, G., Cooper, D.C., Huang, Y., O’Neill, C.E., Yin, H., Zahniser, N.R., Katz, J.L., Rice, K.C., Maier, S.F., Bachtell, R.K., Watkins, L.R.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523496/
https://ncbi.nlm.nih.gov/pubmed/25644383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2014.177
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