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Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression
BACKGROUND AND PURPOSE: Statins decrease heart disease risk, but their mechanisms are not completely understood. We examined the role of the TGF-β receptor III (TGFBR3) in the inhibition of cardiac fibrosis by simvastatin. EXPERIMENTAL APPROACH: Myocardial infarction (MI) was induced by ligation of...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4523335/ https://ncbi.nlm.nih.gov/pubmed/25884615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13166 |
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