Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

PU.1 is a member of the ets family of transcription factors and is expressed exclusively in cells of the hematopoietic lineage. Mice homozygous for a disruption in the PU.1 DNA binding domain are born alive but die of severe septicemia within 48 h. The analysis of these neonates revealed a lack of m...

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Detalhes bibliográficos
Main Authors: McKercher, S R, Torbett, B E, Anderson, K L, Henkel, G W, Vestal, D J, Baribault, H, Klemsz, M, Feeney, A J, Wu, G E, Paige, C J, Maki, R A
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452309/
https://ncbi.nlm.nih.gov/pubmed/8896458
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