A Phase II Study of RO4929097 in Metastatic Colorectal Cancer

BACKGROUND: The Notch signaling pathway is activated in a variety of malignancies and has been implicated in colorectal cancer progression. One of the first steps in the Notch pathway activation is mediated by γ-secretase, a proteolytic enzyme which produces an activated intracellular Notch (ICN). R...

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Detalhes bibliográficos
Publicado no:Eur J Cancer
Principais autores: Strosberg, Jonathan R., Yeatman, Timothy, Weber, Jill, Coppola, Domenico, Schell, Michael J., Han, Gang, Almhanna, Khaldoun, Kim, Richard, Valone, Tiffany, Jump, Helen, Sullivan, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522922/
https://ncbi.nlm.nih.gov/pubmed/22445247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2012.02.056
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