Opposing roles of STAT1 and STAT3 in IL-21 function in CD4(+) T cells

IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of STAT3 in IL-21 signaling. Here, we investigated the role of STAT1 and show that STAT1 and STAT3 hav...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Wan, Chi-Keung, Andraski, Allison B., Spolski, Rosanne, Li, Peng, Kazemian, Majid, Oh, Jangsuk, Samsel, Leigh, Swanson, Phillip A., McGavern, Dorian B., Sampaio, Elizabeth P., Freeman, Alexandra F., Milner, Joshua D., Holland, Steven M., Leonard, Warren J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522759/
https://ncbi.nlm.nih.gov/pubmed/26170288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511711112
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires