Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

In drug discovery, prediction of selectivity and toxicity require the evaluation of cellular calcium homeostasis. The rat is a preferred laboratory animal for pharmacology and toxicology studies, while currently no calcium indicator protein expressing rat model is available. We established a transge...

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Publicado en:Sci Rep
Autores principales: Szebényi, Kornélia, Füredi, András, Kolacsek, Orsolya, Pergel, Enikő, Bősze, Zsuzsanna, Bender, Balázs, Vajdovich, Péter, Tóvári, József, Homolya, László, Szakács, Gergely, Héja, László, Enyedi, Ágnes, Sarkadi, Balázs, Apáti, Ágota, Orbán, Tamás I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522653/
https://ncbi.nlm.nih.gov/pubmed/26234466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12645
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