BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts

BACKGROUND: Germline mutations of the BRCA tumour suppressors have been associated with increased risk of pancreatic cancer. Clinical evidence suggests that these patients may be more sensitive to treatment with cisplatin. As the frequency of germline BRCA mutations is low, definitive experimental d...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Lohse, I, Borgida, A, Cao, P, Cheung, M, Pintilie, M, Bianco, T, Holter, S, Ibrahimov, E, Kumareswaran, R, Bristow, R G, Tsao, M-S, Gallinger, S, Hedley, D W
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522629/
https://ncbi.nlm.nih.gov/pubmed/26180923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.220
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