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The jigsaw puzzle of sequence phenotype inference: Piecing together Shannon entropy, importance sampling, and Empirical Bayes
A nucleotide sequence 35 base pairs long can take 1,180,591,620,717,411,303,424 possible values. An example of systems biology datasets, protein binding microarrays, contain activity data from about 40000 such sequences. The discrepancy between the number of possible configurations and the available...
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| Udgivet i: | J Theor Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522360/ https://ncbi.nlm.nih.gov/pubmed/26092377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2015.06.010 |
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