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Cis-Acting Sequence Elements and Upstream Open Reading Frame in Mouse Utrophin-A 5'-UTR Repress Cap-Dependent Translation

Utrophin, the autosomal homologue of dystrophin can functionally compensate for dystrophin deficiency. Utrophin upregulation could therefore be a therapeutic strategy in Duchenne Muscular Dystrophy (DMD) that arises from mutation in dystrophin gene. In contrast to its transcriptional regulation, mec...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ghosh, Trinath, Basu, Utpal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521823/
https://ncbi.nlm.nih.gov/pubmed/26230628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134809
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