Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

Transforming growth factor-beta (TGF-beta) affects multiple cellular functions through the type I and type II receptor Ser/Thr kinases (TbetaRI and TbetaRII). Analysis of TGF-beta signaling pathways has been hampered by the lack of cell lines in which both TbetaRI and TbetaRII are deleted, and by th...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Luo, K, Lodish, H F
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1996
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452178/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8887540/
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