Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position

The 2-thiouridine (s(2)U) at the wobble position of certain bacterial and eukaryotic tRNAs enhances aminoacylation kinetics, assists proper codon-anticodon base pairing at the ribosome A-site, and prevents frameshifting during translation. By mass spectrometry of affinity-purified native E. coli tRN...

Full description

Saved in:
Bibliographic Details
Published in:J Mol Biol
Main Authors: Rodriguez-Hernandez, Annia, Spears, Jessica L., Gaston, Kirk W., Limbach, Patrick A., Gamper, Howard, Hou, Ya-Ming, Kaiser, Rob, Agris, Paul F., Perona, John J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521407/
https://ncbi.nlm.nih.gov/pubmed/23727144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.018
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items