E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

IL-4/IL-13-induced alternatively activated macrophages (M((IL-4/IL-13)), AAMs or M2) are known to express E-cadherin, enabling them to engage in heterotypic cellular interactions and IL-4-driven macrophage fusion in vitro. Here we show that E-cadherin overexpression in Raw 264.7 macrophages inhibits...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Van den Bossche, Jan, Laoui, Damya, Naessens, Thomas, Smits, Hermelijn H., Hokke, Cornelis H., Stijlemans, Benoît, Grooten, Johan, De Baetselier, Patrick, Van Ginderachter, Jo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521155/
https://ncbi.nlm.nih.gov/pubmed/26226941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12599
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