Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPK(Ser-485) Phosphorylation

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including obesity, diabetes, and dyslipidemia, and insulin resistance (IR) is the central feature of MetS. Recent studies suggest that MetS is a risk factor for Alzheimer disease (AD). AMP-activated kinase (AMPK) is an evolutionar...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Kim, Bhumsoo, Figueroa-Romero, Claudia, Pacut, Crystal, Backus, Carey, Feldman, Eva L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521037/
https://ncbi.nlm.nih.gov/pubmed/26100639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.636852
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