Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline

Untargeted metabolomics has the potential to improve the predictivity of in vitro toxicity models and therefore may aid the replacement of expensive and laborious animal models. Here we describe a long term repeat dose nephrotoxicity study conducted on the human renal proximal tubular epithelial cel...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ranninger, Christina, Rurik, Marc, Limonciel, Alice, Ruzek, Silke, Reischl, Roland, Wilmes, Anja, Jennings, Paul, Hewitt, Philip, Dekant, Wolfgang, Kohlbacher, Oliver, Huber, Christian G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521035/
https://ncbi.nlm.nih.gov/pubmed/26055719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644146
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