Processive ATP-driven Substrate Disassembly by the N-Ethylmaleimide-sensitive Factor (NSF) Molecular Machine

SNARE proteins promote membrane fusion by forming a four-stranded parallel helical bundle that brings the membranes into close proximity. Post-fusion, the complex is disassembled by an AAA+ ATPase called N-ethylmaleimide-sensitive factor (NSF). We present evidence that NSF uses a processive unwindin...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Cipriano, Daniel J., Jung, Jaemyeong, Vivona, Sandro, Fenn, Timothy D., Brunger, Axel T., Bryant, Zev
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520572/
https://ncbi.nlm.nih.gov/pubmed/23775070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476705
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