β-cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

Protection of beta cells from autoimmune destruction potentially cures type 1 diabetes mellitus (T1D). During antigen presentation, interactions between cytotoxic T-lymphocyte antigen-4 (CTLA4) and B7 molecules, or programmed death 1 (PD1) and its ligand PDL1, negatively regulate immune responses in...

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Veröffentlicht in:Gene Ther
Hauptverfasser: El Khatib, Moustafa, Sakuma, Toshie, Tonne, Jason M., Mohamed, Magid S., Holditch, Sara J., Lu, Brian, Kudva, Yogish C., Ikeda, Yasuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520544/
https://ncbi.nlm.nih.gov/pubmed/25786871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.18
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