Specificity of hammerhead ribozyme cleavage.

To be effective in gene inactivation, the hammerhead ribozyme must cleave a complementary RNA target without deleterious effects from cleaving non-target RNAs that contain mismatches and shorter stretches of complementarity. The specificity of hammerhead cleavage was evaluated using HH16, a well-cha...

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Publié dans:	EMBO J
Auteurs principaux:	Hertel, K J, Herschlag, D, Uhlenbeck, O C
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452045/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670879/
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