Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.

We demonstrate that there are at least two S-phase checkpoint mechanisms controlling mitosis in Aspergillus. The first responds to the rate of DNA replication and inhibits mitosis via tyrosine phosphorylation of p34cdc2. Cells unable to tyrosine phosphorylate p34cdc2 are therefore viable but are una...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Ye, X S, Fincher, R R, Tang, A, O'Donnell, K, Osmani, S A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC451970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670863/
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