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Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

Selective inhibition of the inducible isoform of prostaglandin G/H synthase (cyclooxygenase-2; COX2; EC 1.14.99.1) can be achieved with compounds of the general form of aryl methyl sulfonyls and aryl methyl sulfonamides. DuP 697 and NS-398 are representative examples of these compounds. Both inhibit...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Copeland, R A, Williams, J M, Giannaras, J, Nurnberg, S, Covington, M, Pinto, D, Pick, S, Trzaskos, J M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45195/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972034/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.11202
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