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Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
Uracil-DNA glycosylase (UDG) protects the genome by removing mutagenic uracil residues resulting from deamination of cytosine. Uracil binds in a rigid pocket at the base of the DNA-binding groove of human UDG and the specificity for uracil over the structurally related DNA bases thymine and cytosine...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
1996
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC451908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670846/ |
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