The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation.

Most guanine nucleotide binding protein (G protein)-coupled receptors have a conserved cysteine in the C-terminal cytoplasmic tail near the seventh transmembrane spanning region. This cysteine is known to be palmitoylated in rhodopsin, the beta 2-adrenergic receptor (beta 2AR) and the alpha 2A-adren...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Eason, M G, Jacinto, M T, Theiss, C T, Liggett, S B
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45190/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.11178
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