Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease

Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in osteoclast (OC) activation and osteolytic bone diseases in malignancies such as the plasma cell dyscrasia multiple myeloma (MM) is not known...

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Опубликовано в: :J Clin Invest
Главные авторы: Ersek, Adel, Xu, Ke, Antonopoulos, Aristotelis, Butters, Terry D., Santo, Ana Espirito, Vattakuzhi, Youridies, Williams, Lynn M., Goudevenou, Katerina, Danks, Lynett, Freidin, Andrew, Spanoudakis, Emmanouil, Parry, Simon, Papaioannou, Maria, Hatjiharissi, Evdoxia, Chaidos, Aristeidis, Alonzi, Dominic S., Twigg, Gabriele, Hu, Ming, Dwek, Raymond A., Haslam, Stuart M., Roberts, Irene, Dell, Anne, Rahemtulla, Amin, Horwood, Nicole J., Karadimitris, Anastasios
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518690/
https://ncbi.nlm.nih.gov/pubmed/25915583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59987
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