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Theme and variations: evolutionary diversification of the HET-s functional amyloid motif
In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the HET-S Helo-domain pore-forming protein by converting its prion-forming domain into a characteristic β-solenoid amyloid fold. T...
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| Published in: | Sci Rep |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4518210/ https://ncbi.nlm.nih.gov/pubmed/26219477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12494 |
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