Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney

INTRODUCTION: Uncoupling protein 2 (UCP2) reduces production of reactive oxygen species (ROS) by mitochondria. ROS overproduction is one of the major contributors to the pathogenesis of chronic diabetic complications, such as diabetic kidney disease (DKD). Thus, deleterious polymorphisms in the UCP2...

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發表在:PLoS One
Main Authors: de Souza, Bianca Marmontel, Michels, Marcus, Sortica, Denise Alves, Bouças, Ana Paula, Rheinheimer, Jakeline, Buffon, Marjoriê Piuco, Bauer, Andrea Carla, Canani, Luís Henrique, Crispim, Daisy
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517748/
https://ncbi.nlm.nih.gov/pubmed/26218518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132938
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