Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney

INTRODUCTION: Uncoupling protein 2 (UCP2) reduces production of reactive oxygen species (ROS) by mitochondria. ROS overproduction is one of the major contributors to the pathogenesis of chronic diabetic complications, such as diabetic kidney disease (DKD). Thus, deleterious polymorphisms in the UCP2...

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Pubblicato in:PLoS One
Autori principali: de Souza, Bianca Marmontel, Michels, Marcus, Sortica, Denise Alves, Bouças, Ana Paula, Rheinheimer, Jakeline, Buffon, Marjoriê Piuco, Bauer, Andrea Carla, Canani, Luís Henrique, Crispim, Daisy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517748/
https://ncbi.nlm.nih.gov/pubmed/26218518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132938
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