A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer

The mammalian target of rapamycin (mTOR) plays a critical role in promoting tumor cell growth and is frequently activated in breast cancer. In preclinical studies, the antitumor activity of mTOR inhibitors is attenuated by feedback up-regulation of AKT mediated in part by Insulin-like growth factor...

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Udgivet i:Breast Cancer Res Treat
Main Authors: Ma, Cynthia X., Suman, Vera J., Goetz, Matthew, Haluska, Paul, Moynihan, Timothy, Nanda, Rita, Olopade, Olufunmilayo, Pluard, Timothy, Guo, Zhanfang, Chen, Helen X., Erlichman, Charles, Ellis, Matthew J., Fleming, Gini F.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517667/
https://ncbi.nlm.nih.gov/pubmed/23605083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-013-2528-8
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