Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo

Cancer cells secrete VEGF, which plays a key role in their growth, invasion, extravasation and metastasis. Direct cancer cell-endothelial cell interaction, mediated by gap junctions, is of critical importance in the extravasation process. In this study, we evaluated avastin (Av), an anti-VEGF antibo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zibara, Kazem, Awada, Zahraa, Dib, Leila, El-Saghir, Jamal, Al-Ghadban, Sara, Ibrik, Aida, El-Zein, Nabil, El-Sabban, Marwan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517444/
https://ncbi.nlm.nih.gov/pubmed/26218768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12598
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