Long noncoding RNA derived from CD244 signaling epigenetically controls CD8(+) T-cell immune responses in tuberculosis infection

Molecular mechanisms for T-cell immune responses modulated by T cell-inhibitory molecules during tuberculosis (TB) infection remain unclear. Here, we show that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8(+) T cells and that blockade of CD244 signaling...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Yang, Zhong, Huiling, Xie, Xiaodan, Chen, Crystal Y., Huang, Dan, Shen, Ling, Zhang, Hui, Chen, Zheng W., Zeng, Gucheng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517270/
https://ncbi.nlm.nih.gov/pubmed/26150504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501662112
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