Liquid-Phase Synthesis of 2′-Methyl-RNA on a Homostar Support through Organic-Solvent Nanofiltration

Due to the discovery of RNAi, oligonucleotides (oligos) have re-emerged as a major pharmaceutical target that may soon be required in ton quantities. However, it is questionable whether solid-phase oligo synthesis (SPOS) methods can provide a scalable synthesis. Liquid-phase oligo synthesis (LPOS) i...

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Vydáno v:Chemistry
Hlavní autoři: Gaffney, Piers R J, Kim, Jeong F, Valtcheva, Irina B, Williams, Glynn D, Anson, Mike S, Buswell, Andrew M, Livingston, Andrew G
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517100/
https://ncbi.nlm.nih.gov/pubmed/26012874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201501001
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