Translational Development of an ADAMTS-5 Antibody for Osteoarthritis Disease Modification

OBJECTIVE/METHOD: Aggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro, ex vivo and in vivo systems were utilized to assess target engagement, aggrecanase inhib...

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Bibliografiske detaljer
Udgivet i:Osteoarthritis Cartilage
Main Authors: Larkin, Jonathan, Lohr, Thomas A., Elefante, Louis, Shearin, Jean, Matico, Rosalie, Su, Jui-Lan, Xue, Yu, Liu, Feng, Genell, Caroline, Miller, Rachel E., Tran, Phuong B., Malfait, Anne-Marie, Maier, Curtis C., Matheny, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516626/
https://ncbi.nlm.nih.gov/pubmed/25800415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2015.02.778
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