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An Efficient and Cost-effective Approach to Kahalalide F N-terminal Modifications using a Nuisance Algal Bloom of Bryopsis pennata

BACKGROUND: Kahalalide F (KF) and its isomer iso-kahalalide F (isoKF), both of which can be isolated from the mollusk Elysia rufescens and its diet alga Bryopsis pennata, are potent cytotoxic agents that have advanced through five clinical trials. Due to a short half-life, narrow spectrum of activit...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Wang, Bin, Waters, Amanda L., Valeriote, Fred, Hamann, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516563/
https://ncbi.nlm.nih.gov/pubmed/25964068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.05.004
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