eIF2α Confers Cellular Tolerance to S. aureus α-Toxin

We report on the role of conserved stress–response pathways for cellular tolerance to a pore forming toxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to th...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: von Hoven, Gisela, Neukirch, Claudia, Meyenburg, Martina, Füser, Sabine, Petrivna, Maria Bidna, Rivas, Amable J., Ryazanov, Alexey, Kaufman, Randal J., Aroian, Raffi V., Husmann, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515601/
https://ncbi.nlm.nih.gov/pubmed/26284068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00383
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