Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), acute respir...

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發表在:ChemMedChem
Main Authors: von Nussbaum, Franz, Li, Volkhart M-J, Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F, Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A, Tersteegen, Adrian
格式: Artigo
語言:Inglês
出版: WILEY-VCH Verlag 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515084/
https://ncbi.nlm.nih.gov/pubmed/26083237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500131
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