Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response

BACKGROUND: The presence of loss-of-heterozygosity (LOH) mutations in cancer cell genomes is commonly encountered. Moreover, the occurrences of LOHs in tumor suppressor genes play important roles in oncogenesis. However, because the causative mechanisms underlying LOH mutations in cancer cells yet r...

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Detalhes bibliográficos
Publicado no:BMC Med Genomics
Main Authors: Kumar, Yogesh, Yang, Jianfeng, Hu, Taobo, Chen, Lei, Xu, Zhi, Xu, Lin, Hu, Xiao-Xia, Tang, Gusheng, Wang, Jian-Min, Li, Yi, Poon, Wai-Sang, Wan, Weiqing, Zhang, Liwei, Mat, Wai-Kin, Pun, Frank W., Lee, Peggy, Cheong, Timothy H. Y., Ding, Xiaofan, Ng, Siu-Kin, Tsang, Shui-Ying, Chen, Jin-Fei, Zhang, Peng, Li, Shao, Wang, Hong-Yang, Xue, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515014/
https://ncbi.nlm.nih.gov/pubmed/26208496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-015-0104-2
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